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dCeMM2 (Compound 2) is a glue degrader
Coumarin hydrazine is an aromatic hydrazine-containing fluorophores that reacts with aldehyde or ketones for fluorescent labeling
1038/s41589-020-0594-x
1126/sciadv
168 SMILES [H]C(=O)C1=CC=C(OC([2H])([2H])[2H])C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mal-Acetyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB amine-amine dCeMM2 (Compound 2) is aSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or
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