DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan payload Product Name DOTA-PEG2-C2-propanamido-maleimide Synonyms CAS

Product Name DOTA-PEG2-C2-propanamido-maleimide Synonyms CAS Number Related CAS Molecular Formula C29H47N7O12 Molecular Weight 685

324 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(NCCC#C)=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

CA-Oregon Green is a cell permeable HaloTag fluorescent ligand and can be used to label intracellular proteins (496Ex/516Em after hydrolysis)

066 Purity (HPLC) >= 95% Solubility DMSO

Product Name Azide-Lys(m-PEG4)-Val-Cit-OH Synonyms CAS Number Related CAS Molecular Formula C27H50N8O10 Molecular Weight 646

DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan payload Product Name DOTA-PEG2-C2-propanamido-maleimide Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC