Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg S)-AHPC hydrochloride Synonyms VH 032

S)-AHPC hydrochloride Synonyms VH 032 CAS Number 1448189-80-7 Related CAS 1448297-52-6 (free base) Molecular Formula C22H32Cl2N4O3S Molecular Weight 503

88 SMILES: NCCCCC(NS(=O)(=O)C1=CC=C(C(=C1)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S([O-])(=O)=O)C(O)=O

559 Purity (HPLC) >= 95% Solubility DMSO

032 Purity (HPLC) >= 95% Solubility DMSO

558 SMILES NCCOCCNC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg S)-AHPC hydrochloride Synonyms VH 032SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I