Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan aldehyde It induces degradation of SALL4

It induces degradation of SALL4 (ZF2)

high sensitivity (detecting as little as 48 ng/mL enzyme)

making it useful for both short- and long-term imaging applications

Product Name 4-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}butanoic acid Synonyms CAS Number 1240619-81-1 Related CAS Molecular Formula C13H24N2O4 Molecular Weight 272

The TMP-tag is based on the tight binding between trimethoprim (TMP)

Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan aldehyde It induces degradation of SALL4SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The