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431 SMILES CC(C)(C)OC(=O)N1CCN(CCN2CCNCC2)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
352 SMILES [N-]=[N+]=NCCCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Compared to earlier iterations
32 Purity (HPLC) >= 95% Solubility DMSO
Product Name Mal-Propionyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C52H75N9O19 Molecular Weight 1130
Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-Exatecan Thalidomide 431 SMILES CC(C)(C)OC(=O)N1CCN(CCN2CCNCC2)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I
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