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and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators
Product Name DBCO-Lys(m-PEG4)-Val-Cit-PAB-PNP Synonyms CAS Number Related CAS Molecular Formula C60H75N9O16 Molecular Weight 1178
Product Name Thalidomide-5'-O-PEG1-C2-amine HCl Synonyms CAS Number n/a Related CAS Molecular Formula C17H20ClN3O6 Molecular Weight 397
a small enzyme with a high affinity for TMP
Product Name Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C48H74N10O16 Molecular Weight 1047
Propargyl-Gly(m-PEG4)-Val-Ala-PAB Size:10mg and Orally Bioavailable Small-Molecule GSPT1/2SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or
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