Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:25mg CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95%

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

285 SMILES OCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

898 Purity (HPLC) >= 95% Solubility DMSO

757 Purity (HPLC) >= 95% Physical Appearance Yellow solid Optical Properties Abs/Em Maxima: 444/525 nm Solubility DMSO Shipping Conditions Shipped on gel packs Storage Conditions Store at -20°C and protected from light Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Thalidomide-5'-O-C2-alkyne Synonyms CAS Number 2357113-17-6 Related CAS Molecular Formula C17H14N2O5 Molecular Weight 326

Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:25mg CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para