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which binds to DCAF1 with a Kd by SPR and IC50 by TR-FRET of <50 nM
BODIPY (boron-dipyrromethene
Product Name: 5(6)-FAM cadaverine Synonyms: 5-(and 6)-carboxyfluorescein cadaverine CAS Number: N/A Molecular Formula: C26H24N2O6 Molecular Weight: 460
The strain in DBCO’s cyclooctyne ring drives the reaction forward by releasing energy when it transitions to the triazole product
785 Purity (HPLC) >= 95% Solubility DMSO
Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan Size:25mg which binds to DCAF1 withSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by
