DBCO-Dap(m-PEG4)-Val-Cit-PAB-PNP cyclopropene and Orally Bioavailable Small-Molecule GSPT1/2

and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators

CDCF) can passively diffuse into cells and is colorless and nonfluorescent until the acetate groups are cleaved by intracellular esterases to yield the fluorescent fluorophore

CA-TMR has been used for tracking protein localization

394 SMILES OCCCCCCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

S)-AHPC-CO-C5-Br Synonyms CAS Number n/a Related CAS Molecular Formula C28H39BrN4O4S Molecular Weight 607

DBCO-Dap(m-PEG4)-Val-Cit-PAB-PNP cyclopropene and Orally Bioavailable Small-Molecule GSPT1/2SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG,