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The payload is monomethyl auristatin E (MMAE)
CDg18 is the first M2 macrophage selective fluorescent probe
Product Name Lenalidomide-acetamido-O-PEG2-C2-amine HCl Synonyms Lenalidomide-4'-acetamido-O-PEG2-C2-amine HCl CAS Number 2380273-94-7 Related CAS Molecular Formula C21H29ClN4O7 Molecular Weight 484
Product Name DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C65H95N7O20 Molecular Weight 1294
NCCC(=O)NC1=CC=C2C(CN(C3CCC(=O)NC3=O)C2=O)=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP linker The payload is monomethyl auristatinSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further
