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Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay
Product Name Lenalidomide-CO-PEG1-C2-Cl Synonyms Lenalidomide-4'-CO-PEG1-C2-Cl CAS Number n/a Related CAS Molecular Formula C18H20ClN3O5 Molecular Weight 393
SB-715992 CAS Number 336113-53-2 Related CAS Molecular Formula C30H33ClN4O2 Molecular Weight 517
Sulforhodamine 101 is particularly well suited for excitation by the 568 nm spectral line of the Ar – Kr mixed gas laser commonly used in many confocal laser-scanning microscopes or the 594 nm spectral line of the orange He-Ne laser
NCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan protac Development of BODIPY FL ThalidomideSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by
