Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP coumarin Product Name Thalidomide-C4-OH Synonyms Thalidomide-4'-C4-OH

Product Name Thalidomide-C4-OH Synonyms Thalidomide-4'-C4-OH CAS Number n/a Related CAS Molecular Formula C17H18N2O5 Molecular Weight 330

193 Purity (HPLC) >= 95% Solubility DMSO

Binfunctional amine-amine linker

Product Name tert-butyl 4-(3-aminopropyl)piperazine-1-carboxylate Synonyms 1-Boc-4-(3-aminopropyl)piperazine CAS Number 373608-48-1 Related CAS Molecular Formula C12H25N3O2 Molecular Weight 243

Single isomer 6-FAM ethylenediamine

Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP coumarin Product Name Thalidomide-C4-OH Synonyms Thalidomide-4'-C4-OHSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload