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E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin
S)-AHPC-CO-C10-NH2 HCl Synonyms CAS Number 2341796-75-4 Related CAS 2341796-74-3 (free base) Molecular Formula C33H53Cl2N5O4S Molecular Weight 686
Mixed isomer of 5 and 6-FAM ethylenediamine
Product Name Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C94H155N13O29 Molecular Weight 1931
BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-a-brac (BTB) domain of BCL6 with an IC50 of
Propargyl-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE bc E2 enzyme inhibition by stabilizationSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous
