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Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide
Product Name 1-bromo-2-(methoxy-d3)benzene Synonyms 1-bromo-2-(²H3)methoxybenzene CAS Number 892397-56-7 Related CAS Molecular Formula C7H7BrO Molecular Weight 190
126 Purity (HPLC) >= 95% Solubility DMSO
Product Name Azide-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP Synonyms CAS Number Related CAS Molecular Formula C56H89N9O22 Molecular Weight 1240
75 SMILES Cl
DBCO-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:1mg Structure of the DDB1-CRBN E3SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate
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