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DOTA bifucational chelator containing an amine-reactive NHS group
and drug development
Product Name BC-DBCO Synonyms CLIP-DBCO CAS Number Related CAS Molecular Formula C31H27N5O3 Molecular Weight 517
It is preferred for some complicated biological applications where reproducibility is more critical since the minor positional difference between 5-ROX and 6-ROX might significantly affect some biological properties of the underlying conjugates
Product Name Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C46H74N8O17 Molecular Weight 1011
Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE ca DOTA bifucational chelator containing anSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl
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