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DBCO-Lys(m-PEG4)-Val-Ala-PAB dbco-dap-m-PEG4 512 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCC#C)CCN(CC(O)=O)CC1 Purity (HPLC)

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Description

512 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCC#C)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

568 Purity (HPLC) >= 95% Solubility DMSO

Journal of Medicinal Chemistry 2022

Product Name Thalidomide-C4-amine HCl Synonyms Thalidomide-4'-C4-amine HCl CAS Number n/a Related CAS Molecular Formula C17H20ClN3O4 Molecular Weight 365

Product Name Thalidomide-O-C6-amine HCl Synonyms Thalidomide-4'-O-C6-amine HCl CAS Number 2245697-88-3 Related CAS 1957235-98-1 (free base) Molecular Formula C19H24ClN3O5 Molecular Weight 409

DBCO-Lys(m-PEG4)-Val-Ala-PAB dbco-dap-m-PEG4 512 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCC#C)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG,

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